Onodera M, Meyer J, Furukawa K, Hiraoka Y, Aida T, Tanaka K, Tanaka KF, Rose CR, Matsui K* (2021) Exacerbation of epilepsy by astrocyte alkalization and gap junction uncoupling. Journal of Neuroscience, 41: 2106-2118. DOI: https://doi.org/10.1523/JNEUROSCI.2365-20.2020 https://www.jneurosci.org/content/early/2021/01/19/JNEUROSCI.2365-20.2020 Astrocytes have strong control over neuronal excitability and this astrocyte influence are subject to change. Onodera et al. demonstrated that first-time exposure to only brief periods of epileptiform activity resulted in alkaline pH shifts in astrocytes, in gap junction uncoupling, in the hampering of potassium clearance, and in the intensification of epilepsy. Inhibition of this plastic change of astrocyte function could become a promising therapeutic strategy for countering epilepsy development. This international collaboration was carried out mainly between Ko Matsui lab in Tohoku University and Christine Rose lab in Heinrich-Heine-Universität Düsseldorf using the Young Glia framework. @SfNJournals, @TohokuU_Lifesci, @GDecoding, #JNeurosci, #Astrocyte, #Epilepsy, #YoungGlia Press releases
Tohoku University (Japanese) https://www.tohoku.ac.jp/japanese/2021/01/press20210129-03-glial.html Graduate School of Life Sciences, Tohoku University (Japanese) https://www.lifesci.tohoku.ac.jp/research/results/detail---id-49826.html Nikkei 日本経済新聞 https://www.nikkei.com/article/DGXLRSP604169_Z20C21A1000000/ 医療NEWS QLife Pro http://www.qlifepro.com/news/20210201/exacerbation-of-epilepsy.html 2021.01.25 EurekAlert! 2021.01.25 Informationsdienst Wissenschaft 2021.01.25 Bioengineer.org 2021.01.25 MedicalXpress 2021.01.25 ScienMag 2021.01.26 Technology Networks 2021.01.26 The Medical News 2021.01.25 Informationsdienst Wissenschaft 2021.01.25 Bioengineer.org 2021.01.25 MedicalXpress 2021.01.25 ScienMag 2021.01.26 Technology Networks 2021.01.26 The Medical News 2021.01.29 プレスリリース 東北大学 本部 2021.01.29 プレスリリース 東北大学 生命科学研究科 2021.01.29 プレスリリース 日本経済新聞 2021.01.29 東北大学 生命科学研究科 twitter 2021.02.01 東北大学 本部 twitter 2021.02.01 QLifePro - ニュース記事 2021.02.19 Neuro Global twitter 2021.02.21 At one months, Altemtric Score = 94 9 News, 1 Blog, 24 Tweeters 98th percentile of all research outputs tracked (17,060,012) #10 out of 153 outputs (from similar age from J Neurosci) 2021.02.26 ZME Science What is epilepsy: the brain's thunderstorm
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Prof. Dr. Ko Matsui
In search for our mind, we look deeply into the super-network of neurons and glial cells. Graduate School of Life Sciences @ Tohoku University. Archives
February 2024
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