Shimoda Y, Beppu K, Ikoma Y, Morizawa YM, Zuguchi S, Hino U, Yano R, Sugiura Y, Moritoh S, Fukazawa Y, Suematsu M, Mushiake H, Nakasato N, Iwasaki M, Tanaka KF, Tominaga T, Matsui K* (2022) Optogenetic stimulus-triggered acquisition of seizure resistance. Neurobiology of Disease, 163: 1055602. DOI: https://doi.org/10.1016/j.nbd.2021.105602 https://www.sciencedirect.com/science/article/pii/S096999612100351X?via%3Dihub Tohoku University scientists have shown that resilience to epilepsy could be acquired with certain stimulation paradigm using experimental animals. Frequent occurrence of neuronal hyperactivity and seizures has been shown to induce epileptogenesis. Here, we show that daily neuron-to-astrocyte signaling could prompt release of endogenous inhibitory transmitter, adenosine, from glial cells. The novel neuronal stimulation protocol brought out the homeostatic potential of glial cells and converted the brain of the rat to a state that is strongly resistant to seizure induction.
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Prof. Dr. Ko Matsui
In search for our mind, we look deeply into the super-network of neurons and glial cells. Graduate School of Life Sciences @ Tohoku University. Archives
February 2024
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