Excited to announce our new paper published in the journal, Brain. Optical fibers were used to probe the glial and vascular reactions in epilepsy using a mouse model. A new design FRET fiber photometry method offers detection of Ca2+, pH, and brain blood volume dynamics. Early epileptic seizures produced astrocytic alkalization while developed seizures resulted in acidification in the lateral hypothalamus. This dual phase pH reaction of astrocytes suggests a need for individualized medicine depending on the stage for the possible prevention and treatment of epilepsy.
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Prof. Dr. Ko Matsui
In search for our mind, we look deeply into the super-network of neurons and glial cells. Graduate School of Life Sciences @ Tohoku University. Archives
February 2024
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