Super acidified to announce our new paper!! Using the new design FRET fiber photometry method, acid shifts were captured in the dreaming glia.
* Please use twitter and tweet including the DOI or retweet to my tweet below to contribute to increasing our Altmetric score and supporting our science! Ikoma Y, Takahashi Y, Sasaki D, Matsui K (2023) Properties of REM sleep alterations with epilepsy. Brain DOI: https://doi.org/10.1093/brain/awac499 Professor Ko Matsui's tweet (please retweet. Like! does not count in Altmetric): https://twitter.com/KoMatsui/status/1631568237686296576 Upon REM sleep, astrocytes reacted with acidic shifts, calcium reduction and vascular expansion. These local brain environmental changes preceded the REM shifts detected with EEG by ~20 sec. Artificial acidification of astrocytes in lateral hypothalamus with photoactivation of ChR2 expressed in astrocytes induced a REM-like shift in behavior and EEG. These data suggest that astrocyte and vascular changes may serve as one of the drives to brain state changes. Furthermore, the acid response in REM sleep was exacerbated after the epileptic kindling protocol. REM sleep characteristics may provide a biomarker for the severity of epilepsy. Controlling of astrocytes' pH could potentially be used for the prevention of epileptogenesis. Super-network Brain Physiology Grad Sch Life Sci, Tohoku Univ http://www.ims.med.tohoku.ac.jp/matsui/
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Prof. Dr. Ko Matsui
In search for our mind, we look deeply into the super-network of neurons and glial cells. Graduate School of Life Sciences @ Tohoku University. Archives
February 2024
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